>topA.TIGR01051
LVIVESPAKAKTIKKYLG-DEYEVEASMGHIRDLPKS-----------------------------RLGVDIEKD--FEPEYVVSKGKKKVVKELKTLAKKADEVYLATDPDREGEAIAWHLAEVLKPKDPV-----YKRIVFNEITKKAIRAALKNPREIDMNLVNAQQARRILDRLVGYTLSPLLWKKVAKGLSAGRVQSVALRLIVDREREIKRFVPEEYWTIDATFQK-------GEETFEALLTEVNGKKLKAGSD----------------LDEAEATALKEQLKGEELVVEEIEKKPKKSRPPPPFTTSTLQQEASRKLGFSAKKTMMIAQRLYEGVSTG-DGTIGLITYMRTDSTRLSNQAVNEARNLIDKNYGKEYLGPKPK--RYKSKEKNAQEAHEAIRPT-SVFRTPEELKDYLKR---DEFRLYELIWKRFVASQMADARYDSTSVRLTNEDG--------EYVFKATGRKLIFDGYYKVYVEGSDDP----LEEKDRILPPLKEGDAVKLVEVKPNQHFTQPPARYTEASLVKELEELGIGRPSTYASIISTIQDRGYVKKENKRLYPTELGFAVTDLLEKHFGDVVDYDFTAKMEKDLDEIAEGKAEWKPVLKNFYTGFSSKVKK------------LRNMRIIVDF---KTSQDCPLCGR-PMVVKLGKYG--PFLACSN--------FPECKYTKSIV
>gi|99032438|pdb|2GAI|A
YIVVESPAKAKTIKSILG-NEYEVFASMGHIIDLPKS-----------------------------KFGVDLEKD--FEPEFAVIKGKEKVVEKLKDLAKK-GELLIASDMDREGEAIAWHIARVTNTLGRK------NRIVFSEITPRVIREAVKNPREIDMKKVRAQLARRILDRIVGYSLSPVLWRNFKSNLSAGRVQSATLKLVCDREREILRFVPKKYHRITV--------------NFDGLTAEIDVKEKKF----------------------FDAETLKEIQSIDELVVEEKKVSVKKFAPPEPFKTSTLQQEAYSKLGFSVSKTMMIAQQLYEGVETK-DGHIAFITYMRTDSTRVSDYAKEEARNLITEVFGEEYVGSKRE--RRKSNAK-IQDAHEAIRPT-NVFMTPEEAGKYLNS---DQKKLYELIWKRFLASQMKPSQYEETRFVLRTKDG--------KYRFKGTVLKKIFDGYEKVWKTER----------NTGEFP-FEEGESVKPVVVKIEEQETKPKPRYTEGSLVKEMERLGIGRPSTYASTIKLLLNRGYIKKIRGYLYPTIVGSVVMDYLEKKYSDVVSVSFTAEMEKDLDEVEQGKKTDKIVLREFYESFSSVFD--------------RNDRIVVDF---PTNQKCS-CGK-EMRLSFGKYG--FYLKC------------ECGKTRSVK
>gi|6094493|sp|O83409.1|TOP1_TREPA
LVIVESPAKAQTIEKYLG-TQYVVRASMGHVIDLPKS-----------------------------RLAIDIEHD--FQPEYITVRGRAQCLKELRTLSKQSLQVFLASDRDREGEAIAYHLAQSIQAYCDTP----IKRIVFNEITPHAIRAAIGHPVPIDTAKVNAQKARRVLDRLVGYHLCPLLWHKVKNGLSAGRVQSVALRLICEREVEVKRFVPEEYWTVEGTFEK-------DKKSFSALLILIQGKKAVFKS-------------------KQEATSAIGLFSQSEARVSQIRSFEKNVRPKQPFTTSTLQQCAANRLGFTSRKTMQVAQQLYEGVSLG-THRVGLITYMRTDSVRVSEAAVKEVRAWIATHFSDALPGTPN---RYAAKGK-SQDAHEAIRPT-YVAHTPERIKAHLTR---DQIRLYTLIWERFVASQMTDARVRSLTFEITA--G--------PAVFSATETQVIEQGFYRVLKMLSPK------DLSKAVLPPTKEGEVVALHNVQSVQHFTQGPVRYTDASIVKMLEEKGIGRPSTYAPTISVLLDRYYVTRIQKQLMPTPLGKVISDLLTTYFHDVVDVSFTARMESKLDEVEEDKIKWNCVIADFYPAFSEKVSTVM--------KDLNSMRGVFDE---KTDVVCSQCGD-TMVKKLGRFG--FFLACGK--------FPECRNTQPVP
>gi|1174737|sp|P46799.1|TOP1_THEMA
YIVVESPAKAKTIKSILG-NEYEVFASMGHIIDLPKS-----------------------------KFGVDLEKD--FEPEFAVIKGKEKVVEKLKDLAKK-GELLIASDMDREGEAIAWHIARVTNTLGRK------NRIVFSEITPRVIREAVKNPREIDMKKVRAQLARRILDRIVGYSLSPVLWRNFKSNLSAGRVQSATLKLVCDREREILRFVPKKYHRITV--------------NFDGLTAEIDVKEKKF----------------------FDAETLKEIQSIDELVVEEKKVSVKKFAPPEPFKTSTLQQEAYSKLGFSVSKTMMIAQQLYEGVETK-DGHIAFITYMRTDSTRVSDYAKEEARNLITEVFGEEYVGSKRE--RRKSNAK-IQDAHEAIRPT-NVFMTPEEAGKYLNS---DQKKLYELIWKRFLASQMKPSQYEETRFVLRTKDG--------KYRFKGTVLKKIFDGYEKVWKTER----------NTGEFP-FEEGESVKPVVVKIEEQETKPKPRYTEGSLVKEMERLGIGRPSTYASTIKLLLNRGYIKKIRGYLYPTIVGSVVMDYLEKKYSDVVSVSFTAEMEKDLDEVEQGKKTDKIVLREFYESFSSVFD--------------RNDRIVVDF---PTNQKCS-CGK-EMRLSFGKYG--FYLKC------------ECGKTRSVK
>gi|730965|sp|P39814.1|TOP1_BACSU
LVIVESPAKAKTIERYLG-KKYKVKASMGHVRDLPKS-----------------------------QMGVDIEQN--FEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDLNS-----DCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKKGLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLK-------GQETFEASFFGKNGKKLPLNS-------------------EADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRK--PAKKNEN-AQDAHEAIRPT-SVLRKPSELKAVLGR---DQMRLYKLIWERFVASQMAPAVLDTMSVDLTN--N--------GLTFRANGSKVKFSGFMKVYVEGKDDQ----MEEKDRMLPDLQEGDTVLSKDIEPEQHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQIVLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAE---------SEMKEVEIEPE---YAGEDCELCSS-PMVYKMGRYG--KFLACSN--------FPDCRNTKPIV
>gi|730966|sp|P06612.2|TOP1_ECOLI
LVIVESPAKAKTINKYLG-SDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHN--WEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDAR-----YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT------PSGEALALQVTHQNDKPFRPVN-------------------KEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPN--QYASKEN-SQEAHEAIRPS-DVNVMAESLKD-MEA---DAQKLYQLIWRQFVACQMTPAKYDSTTLTVGA--G--------DFRLKARGRILRFDGWTKVMPALRKG-------DEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEK------DPEEGGMRPNQMV---LTSIDCPTCGR-KMGIRTASTG--VFLGCSGYAL---PPKERCKTTINLV
>gi|2501241|sp|P73810.1|TOP1_SYNY3
LVIVESPTKARTIRNYLP-QDYRVEASMGHVRDLPASAEEVPAA---------------YKDKSWANLGVNVEDH--FSPLYVIPKSKKKVVKELQTALKNADEVILATDEDREGESISWHLLQLLQPKVPI------KRMVFHEITQEAIRSALENCRDIDENLVHAQETRRILDRLVGYTLSPLLWKKIAWGLSAGRVQSVAVRLIVQRERARRAFKTAGYWDLKAELEQ-------NKNPFQAKLMTLGGTKLANGSDFDPNTGALLPDKQVVVLDEAQAIALKERLTGKPWAVVNTEEKPGVRKPSPPFTTSTLQQEANRKLGISARDTMRVAQKLYEE---------GYITYMRTDSVHLSDQAVTAARNCVQQMYGKEYLSPQPK--QYTTKSKGAQEAHEAIRPAGTEFRIPNQTG--LKD---RELALYELIWKRTVACQMADARITQLSVLLKVEDA----------EFRAAGKRIDFPGYFRAYVEGSDDPDA-ALENQEVILPPLKVGDRPNCREIDTVGHETQPPARYTEASLVKTLESEGVGRPSTYASIIGTIIDRGYVQMRSKALTPTFTAFAVVSLLESHFPDLVDTGFTSRMEQKLDEIAIGKTQWLPYLQGFFLGESGLEN-----------QVKVRQDQIDP----AIAKAIELENL-AAKVKIGKFG--PYIEIPQGE-----EIITASIPQDLT
>gi|6686044|sp|Q9ZDK2.1|TOP1_RICPR
LVIVESPAKAKTINKYLG-DEFKVIASFGHIRDLPSK-----------------------------KGSVLPDKN--FLMEYDISDKAGKYVDAIVKEARKAEVVYLATDPDREGESISWHVAEVIKEKNKVESDDFFKRVAFNEITKKAIMNAVANPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICDREDEIERFKSEEYWDISLKMQN------SNNDLFTAKLTHVNDQKLKKFSI----------------INEKEAKDLTQKLKLQKFYVEKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIG-KETIGLITYMRTDGVTLSNDAIADIRKLIDKNYGNQYLPIKPR--IYQSKVKNAQEAHEAIRPT-NITYTPDSLKQKLEK---DYYKLYELIWHRTIACQMENVIMDLVIANLASENK--------EYLAKANGSIIAFDGFYKVYRESLDDE----DEEDNKMLPPLKEQEHIKTKEVIPNKHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKTALNNFWRGFNHNIESVNEQKITEIINYLQKALDYHLFGEDKESKVCPSCKTGQLSLKLGKFG--AFLACSN--------YPECTFKKSIV
>gi|2501238|sp|P55991.1|TOP1_HELPY
LIIVESPAKAKTIKNFLD-KNYEVIASKGHVRDLSKF-----------------------------ALGIKIDETG-FTPNYVVDKDHKELVKQIIELSKKASITYIATDEDREGEAIGYHVACLIGGKLES-----YPRIVFHEITQNAILNALKTPRKIDMSKVNAQQARRFLDRIVGFKLSSLIASKITKGLSAGRVQSAALKLVIDKEREIKAFKPLTYFTLDAYF----------ESHLEAQLISYKGNKLKAQEL----------------IDEKKAQEIKNELEKESYAISSIVKKSKKSPTPPPFMTSTLQQSASSLLGFSPTKTMSIAQKLYEGVATP-QGVMGVITYMRTDSLNIAKEALEEARNKILKDYGKDYLPPKAK--VYSSKNKNAQEAHEAIRPT-SIILEPNALKDYLKP---EELRLYTLIYKRFLASQMQDALFESQSVVVACEKG----------EFKASGRKLLFDGYYKILGND----------DKDKLLPNLKENDPIKLEKLESNAHVTEPPARYSEASLIKVLESLGIGRPSTYAPTISLLQNRDYIKVEKKQISALESAFKVIEILEKHFEEIVDSKFSASLEEELDNIAQNKADYQQVLKDFYYPFMDKIEA-------------GKKNIISQKVHEKTGQSCPKCGG-ELVKKNSRYG--EFIACNN--------YPKCKYVKQTE
>gi|1351261|sp|P47368.1|TOP1_MYCGE
LVVIESPNKVKTLKQYLPSDEFEIVSTVGHIREMVYKNFGFD-------------------ENTYTPIWEDWTKNKQKNPKQKHLLSKFEIIKSIKAKASDAQNIFLASDPDREGEAISWHVYDLLDQKDKAK----CKRITFNEITKKAVVDALKQPRNIDLNWVESQFARQILDRMIGFRLSRLLN-SYLQAKSAGRVQSVALRFLEEREKEIAKFVPRFWWTVDVLLNKENNQKVVCANKSIPLVLREINPELSASLKLDFEAAE--NVSGIDFLNEASATRFANQLTGEYEVYFIDEPKIYYSSPNPVYTTASLQKDAINKLGWSSKKVTMVAQRLYEGISVN-GKQTALISYPRTDSIRISNQFQSECEKYIEKEFGSHYLADKNKLKRHKKDEKIIQDAHEGIHPT-YITITPNDLKNGVKR---DEFLLYRLIWIRTVASLMADAKTSRTIVRFINQKN----------KFYTSSKSLLFDGYQRLYEEIKPNT----KDELYIDLSKLKIGDKFSFEKISVNEHKTNPPPRYTQASLIEELEKSNIGRPSTYNTMASVNLERGYANLVNRFFYITELGEKVNNELSKHFGNVINKEFTKKMEKSLDEIAENKVNYQEFLKQFWTNFKSDVKL------------AENSIQKVKKEKELVERDCPKCNQ-PLVYRYTKRGNEKFVGCSD--------FPKCKYSEFSN
>gi|653293189|ref|WP_027480031.1|
LVIVESPAKAKTIEKYLG-QGYAVESSVGHIRDLPRSAADIPEK---------------YKGQAWARLGLDVEHD--FQPLYVVSPEKKQKVAQLRKLAAEADEIILATDDDREGESIAWHLYQELKPKVPV------KRMVFHEITREAIQAAIAAPRQIDRNLVEAQEARRAVDRLYGYEVSPVLWRKVAPKLSAGRVQSVATRMLVERERERMRFVAATWWDVVVTAQALT--AQAGEQTFPARLTEVQGERLAAGKDFDPLTGQLRPGAGVRLLGEAEALAISEGLKGQTLKVLTAEEKPFTSRPPAPFITSTLQQEGSRKLRMSAQTTMRTAQRLYEG---------GYITYMRTDSTNLSSEAVNAARGQVKDMYGAPYLSPQPR--VYAKKSKNAQEAHEAIRPAGSTFRTPEQLRGELSG---DEWRLYDLIWKRTVASQMSDARGRSLRVRLGGQTASGQTADSVPVVLNASGRTIDFPGFLRAYVEGSDDPAA-ALEDRDTPLPPLKAGDAVRAQDVKAEDHETQPPARYTEASLVQALEGAGIGRPSTYASILGTIQDRGYALKKGTALVPSWTAFATSALLEHHFGTLVDYDFTAKMEEDLDEIAGGREHRVPYLRRFYLGEEGEGMAL-------KPLIERQMGEIDARGIATIKVP-KLEGS-GIEVRVGRYG--PYMQRGE---------DKANLPEGMT
>gi|6226905|sp|Q59567|TOP1_MYCTU
LVIVESPTKARKLASYLG-SGYIVESSRGHIRDLPRAASDVPAK---------------YKSQPWARLGVNVDAD--FEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPV------KRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSLGTLR-KGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYEN---------GYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPR--QYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARGMTLSLRITGMSGH------QEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGR-PIYVRVGKNG--PYLERLVAGDTGEPTPQRANLSDSIT